Interestingly, when we fed larvae with MB at 20 μM, MB effectively rescued bouton number loss in larvae overexpressing PAR1 or human tau R406W (htauM, a pathogenic form of tau related to tauopathy) under the control of Mhc-Gal4 driver (Fig. 1b–d). The gene discussed is HLA-C; the disease is tauopathy.