Recently it has been reported that miR-188-3p targets β site cleavage enzyme (BACE1) and miR-188-3p expression was significantly down-regulated both in the brains of AD humans and 5XFAD mice and that miR-188 expression is regulated by 2-arachidonoyl glycerol or peroxisome proliferator-activated receptor-γ (PPARγ) agonists42. This evidence concerns the gene BACE1 and Alzheimer disease.