APP and Alzheimer disease: Moreover, the impairments in cognitive function and synaptic transmission observed in 7-month-old 5XFAD transgenic mice, which harbor 3 familial AD mutations of APP 695, namely the Swedish, Florida, and London mutations and 2 presenilin1 (PSEN1) mutations (M146L and L286V), were ameliorated via viral-mediated expression of miR-188-5p.