SHANK genes are likely causative for ASDs33, CACNA1D (CaV1.3 α1-subunit) is an identified ASD risk gene18, 23, 24 and may be critical for loss of synapse stability in Parkinson’s disease14, and densin-180 knockout mice display symptoms related to schizophrenia and ASDs34. Here, SHANK2 is linked to schizophrenia.