Considering the previous report that TGF-β expressing CD11b+ recruited Mφs accelerate hepatic fibrosis in CCl4 induced liver cirrhosis4, DP Kupffer cells/Mφs may be associated with hepatic fibrosis and repair (M2 Mφs)31, 32 in this model. Here, TGFB1 is linked to Hepatic fibrosis.