However, although the liver (hepatocytes) itself is not such a radio-sensitive organ44, we cannot exclude the possibility that low dose radiation therapy may increase the susceptibility to hepatocellular carcinoma in NASH patients because of depletion CD11b+ recruited Kupffer cells/Mφs and resultant inactivation of NK cells and NK-T cells. This evidence concerns the gene ITGAM and metabolic dysfunction-associated steatohepatitis.