INS and Hyperglycemia: Increased expression levels of SREBP1c, ACC and FAS in the LIrs1/2DKO mice to levels similar to those in the control mice in the fed state are probably attributable to the severe hyperglycaemia in the LIrs1/2DKO mice, which has been reported to upregulate SREBP1c expression, in addition to insulin signalling17, 18.