SREBF1 and Insulin resistance: Although it has been reported previously that ‘selective insulin resistance' is induced by sustained activation of SREBP1c via the mTORC1 pathway even under insulin resistance conditions18, 37, 38, we did not find any significant differences in the expression levels of the precursor or mature forms of SREBP1c protein between the control and LIrs2KO mice (Supplementary Figs 6 and 8).