Casp1/11−/− DIO mice had significantly reduced tumour growth compared with WT DIO mice (Fig. 2b), but CASP1/11 deficiency had no impact on tumour growth in normal-weight mice (Fig. 2b), suggesting that simply gaining body weight in the Casp1/11−/− mice is no longer sufficient for tumour growth. This evidence concerns the gene CASP1 and neoplasm.