We found that tumour-infiltrating CD11b+ cells were the primary source of Nlrc4 in both Py8119 (Fig. 3e) and E0771 (Fig. 3f) tumours, and that obesity further upregulated its expression (Fig. 3e,f, open bars). The gene discussed is ITGAM; the disease is obesity due to melanocortin 4 receptor deficiency.