As these data suggest that NLRC4 inflammasome/IL-1β drives obesity-associated tumour angiogenesis through a signalling network between macrophages and adipocytes, we stained tumour sections for adipocytes and found a general increase in lipid droplets of tumours from DIO mice compared with ND mice (Supplementary Fig. 5g). Here, NLRC4 is linked to obesity due to melanocortin 4 receptor deficiency.