ITGAM and neoplasm: Using NLRC4-Flag knock-in mice24 we detected two isoforms of NLRC4, isoform 1 (114 kd) and isoform 2 (44 kd) in tumour-infiltrating CD11b+ cells from DIO mice, but no NLRC4 expression could be detected in CD11b− cells (Fig. 3g and Supplementary Fig. 4f).