MEK-162 treatment of murine corticotroph tumor cells reduced TR4 mRNA (Mean ± SE, TR4 mRNA FD, Vehicle: 1.0±0.01, MEK-162 20 μM: 0.9±0.003, p < 0.01; MEK-162 40 μM: 0.7±0.01, p < 0.005, Figure 4A). This evidence concerns the gene NR2C2 and neoplasm.