MAP2K7 and neoplasm: In contrast to our finding that reduced TR4 expression blunted MEK-162 actions, TR4 overexpression in murine corticotroph tumor cells augmented the MEK-162 mediated inhibition of cell proliferation (Mean ± SE, proliferation FD, Vehicle: 1.0±0.04; MEK-162 20 μM: 0.5±0.003, p < 0.005; MEK-162 40 μM: 0.3±0.004, p < 0.005, Figure 3E) compared to vehicle-treated control transfectants (Mean ± SE, proliferation FD, Vehicle: 1.0±0.1; MEK-162 20 μM: 0.8±0.04; MEK-162, 40 μM: 0.5±0.01, p < 0.05, Figure 3E).