To further investigate MEK-162 treatment effects on TR4 corticotroph tumor action, we compared the anti-proliferative effect of MEK-162 treatment in the presence of varying TR4 levels, including knockdown of TR4 by shRNA (Figure 3A) and overexpression of a V5-tagged TR4 construct (Figure 3D). This evidence concerns the gene NR2C2 and neoplasm.