ApoE knockout mice have been used as a model of AD as they exhibit mild neurodegenerative changes and behavioural abnormalities relevant to the early stages of this disorder, including synaptic and dendrite loss, lipid peroxidation, cellular stress, behavioural alterations in Morris water maze test and deficits in long-term potentiation (LTP) [26–30]. This evidence concerns the gene APOE and Alzheimer disease.