In order to evaluate the function of NRIP1 in cell growth, apoptosis and inflammation involved in psoriasis, we used human skin biopsies and peripheral blood mononuclear cells (PBMCs), HaCaT cells and CD4+ T cells isolated from psoriasis patients, along with an in vivo study of IMQ-induced psoriasis in Nrip1 knockout mice. This evidence concerns the gene CD4 and psoriasis.