Herein, we 1) investigate the prognostic role of CD66b+ TANs in primary tumors of NSCLC patients stratified into SCC and ADC subgroups, 2) assess the prognostic effect of intraepithelial CD66b+ TANs in metastatic lymph nodes from N+ patients and 3) correlate the presence of CD66b+ TANs with 104 tumor molecular markers previously evaluated in this same cohort. This evidence concerns the gene CEACAM8 and neoplasm.