In contrast, incubation of the same donor PBMC with primary patients' ALL blasts led to a significant reduction in IFN-γ secretion and T-cell proliferation (0.3%±0.0 IFN-γ+CD3+ T cells (n=3) and CD3+ T-cell proliferation of 12.7%±8.6; n=7). Here, IFNG is linked to acute lymphoblastic leukemia.