Since NF-κB is generally less associated with the metastatic activities of malignant tumors, other targets of NAG-1, including AKT, ERK1/2 [54, 78], and FAK-RhoA GTPase [79] may also contribute to distant metastasis via enhanced locomotive activity and resistance to anoikis stress during migration in the circulation [80]. Here, RHOA is linked to cancer.