Other early-stage candidate genes in this network that may be involved in tumorigenesis, include RARRES3, GRB10, INNP1 and EPOR. RARRES3 is thought to act as a tumor suppressor or growth regulator that suppresses metastasis; it has also been associated with the modulation of the acylation status of Wnt proteins to suppress EMT and cancer stem cell properties [39]. This evidence concerns the gene PLAAT4 and cancer.