The edema volume of the infarction, which was determined with EB extravasation in coronal sections taken through the front and rear of the center of the lesions in Cav-1 OE rats, was significantly lower (81.6 ± 7.3 mm3) 3 d after ischemia than the volumes in the control (136.6 ± 11.7 mm3, P < 0.01) and EC groups (141.4 ± 18.3 mm3, P < 0.01; Figure 4C). Here, CAV1 is linked to ischemia.