In addition, Figure 4B shows that EB extravasation following ischemia in the ipsilateral hemisphere was significantly decreased in the Cav-1 OE rats (11.9 ± 1.9 μg/g tissue) compared with the control (22.6 ± 2.1 μg/g tissue, P < 0.01) and EC groups (20.9 ± 2.0 μg/g tissue, P < 0.01). Here, CAV1 is linked to ischemia.