Months later, however, when the same dose of isopentaquine was administered with an oral 500 mg dose of methylene blue (MB; methylthioninium chloride), the subject completed the 14-day regimen without signs of hemolysis.133 However, smaller daily doses of MB administered to G6PD-deficient African children with acute falciparum malaria resulted in slightly more posttreatment hemolysis than in G6PD-normal children.134. This evidence concerns the gene G6PD and Plasmodium falciparum malaria.