Considering our results described above that show massive expansion, activation, tissue homing, and cytotoxic effector phenotypes of the two activated CD8 T cell subsets in dengue patients, it was of interest to examine what fraction of these cells produce IFN-γ, what is the breadth of the response, and which of the two activated CD8 T cell subsets contains the IFN-γ-producing cells. Here, IFNG is linked to dengue disease.