Because our phenotypic and transcriptomic analyses showed that these activated CD8 T cell subsets from dengue patients upregulate several negative costimulatory molecules, such as PD-1, Lag3, KLRG1, CTLA-4, and CD160, one would suspect that these cells may be subjected to IFN-γ repression in a manner similar to that of the exhausted CD8 T cells in chronic infections. This evidence concerns the gene CTLA4 and dengue disease.