From these results, we conclude that these massively expanding, highly activated, cytotoxic effector CD8 T cells in dengue fever patients are indeed capable of making IFN-γ upon stimulation in vitro with a strong TCR-independent stimulus but do not make it with TCR-dependent stimuli, probably due to TCR signaling insufficiencies, as suggested by our transcriptomic analysis. This evidence concerns the gene CD8A and dengue disease.