The increased glomerular volume and mesangial matrix index from WT T2D mice were also partially rescued by NLRC4-deficiency, with glomerular volume decreased from 9.8±1.3 to 7.4 ±0.9 x 105 (μm3) and mesangial matrix index from 42.4±7.9 to 39.5±4.4 x 10−2 (Table 1). Here, NLRC4 is linked to type 2 diabetes mellitus.