Our hypotheses were that (I) cognitive impairment would be observed in both age groups, being more pronounced in the older caregivers; (II) hormonal and BDNF levels would be altered in the caregivers, with greater stress effects on older caregivers, and (III) hormonal and BDNF levels would be significantly related with the cognitive performance of caregivers. Here, BDNF is linked to Cognitive impairment.