Our study suggest longitudinal declines of pFEV1 in subjects with SHPTB on CXR manifestation in an intermediate TB burden country like South Korea; in our study we excluded all the subjects who have the history of TB medication or TB treatment, although latent TB infection was not confirmed by diagnostic tool such as tuberculin skin test (TST) or interferon gamma release assay (IGRA). The gene discussed is IFNG; the disease is tuberculosis.