LIAS and liver dysplastic nodule: In the current studies, we consolidate our previous observation that mitochondrial damage in proximal tubules is a predominant pathological feature of DN by demonstrating that reduction in Lias gene expression in LiasLow/LowIns2Akita/+ mice and increased Lias expression in LiasHigh/HighIns2Akita/+ mice impact mitochondrial integrity and function.