Dai et al. showed that GOLPH3 activates NF-κB pathway in HCC [42], while Zeng et al. proved that overexpression of GOLPH3 inhibits transcriptional activity of FOXO1 and, as a consequence, facilitates G1–S-phase transition in breast cancer cells [43]. The gene discussed is NFKB1; the disease is hepatocellular carcinoma.