Increased immunoreactivity of GOLPH2 and GOLPH3 in melanoma cells was statistically linked with thicker tumors, regional lymph node metastases (only SLN metastases for GOLPH3), locoregional recurrence, lymphangioinvasion, presence of ulceration, higher mitotic rate, and lower TIL (tumor-infiltrating lymphocytes) grade (Table 1, Table 2, Table 3 and Table 4). This evidence concerns the gene GOLPH3 and melanoma.