HIF-1α promotes collagen biogenesis and alignment in breast tumors by the transcriptional activation of collagen prolyl (P4HA1 and P4HA2) and collagen lysyl (PLOD1 and PLOD2) hydroxylases (Figure 1) [70,71,72] as well as lysyl oxidase family members (LOX, LOXL2, LOXL4) under hypoxia [73,74]. The gene discussed is LOX; the disease is breast neoplasm.