Nowadays, anti-hypertensive medications namely, analapril and captopril marketed under the trade names Accupril, Capoten, Altace, Lotensin, Prinvil, Vasotec, Monoril, Zestril and other synthetic ACE inhibitors such as Ramipril and Lisinopril are applied extensively in the clinical therapy of hypertension and also heart failure in humans. The gene discussed is ACE; the disease is hypertensive disorder.