Interestingly, combined treatment with OP449 and dovitinib induced both OP449- and dovitinib-mediated effects and blocked the phosphorylation of c-MYC, AKT, ERK1/2, p70S6, and pan-phosphotyrosine activity in both NOTCH-dependent and independent T-ALL cell lines. The gene discussed is AKT1; the disease is acute lymphoblastic leukemia.