Additionally, we discovered that the apoE-mimetic peptide OP449 (formerly COG449, Oncotide Inc) [32, 33] inhibits SET, resulting in restoration of PP2A tumor suppressor activity in chronic myelogenous leukemia (CML) and acute myelogenous leukemia (AML) [34]. The gene discussed is APOE; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.