KRAS and familial pancreatic carcinoma: As for somatic KRAS mutations reported in PDAC (COSMIC and ICGC data) and chronic pancreatitis (COSMIC data), the majority of cfDNA KRAS mutations identified in the combined pilot and validation series were located at codon 12 (76.3 % in pancreatic cancer cases; 77.8% in chronic pancreatitis and 47.4% in healthy controls; Figure 2A).