KRAS and neoplasm: The frequencies of the most predominant mutation types reported for PDAC in ICGC, i.e p.G12D, p.G12V, p.G12R, p.G12C followed by p.Q61H, p.Q61R and p.Q61L paralleled the frequencies of the cfDNA KRAS mutations in cases (Figure 2B) reflecting the probable tumor origin of the cfDNA KRAS mutations.