Applying a threshold of QVAL >30 to the sample set of the pilot series, KRAS mutations at hotspot codons reported in PDAC were identified in cfDNA plasma samples in 7 of 40 cases (sensitivity 17.5%) with PDAC and in 1 cfDNA of 27 patients with pancreatic benign neoplasms. The gene discussed is KRAS; the disease is benign neoplasm of pancreas.