MAPK14 and cancer: Indeed, HS06 caused a robust 1.7 to 2.3-fold increase in phosphorylated form of p38 at 3 h in various colorectal (HCT116 & HT29), pancreatic (Panc-1), and breast (MDA-MB-231) cancer spheroids, but not in their monolayer counterparts (Figure 6a).