Considering the high clinical utility of the appropriate polyp classification, in this study, we evaluated the potential of colonic mucins (MUC1, MUC4, MUC17, MUC2, MUC5AC, and MUC6) and associated glycans (Tn/STn-MUC1 and CA19-9) for differentiating SSA/P from HP and TA. The gene discussed is MUC4; the disease is hyperplastic polyp.