Considering the high clinical utility of the appropriate polyp classification, in this study, we evaluated the potential of colonic mucins (MUC1, MUC4, MUC17, MUC2, MUC5AC, and MUC6) and associated glycans (Tn/STn-MUC1 and CA19-9) for differentiating SSA/P from HP and TA. This evidence concerns the gene MUC5AC and hyperplastic polyp.