Aberrant SALL4 expression has been reported in a myriad of solid tumors including HCC [15, 16, 31], endometrial cancer [19], ovarian cancer [32], breast cancer [33], gastric cancer [18, 34], lung cancer [20, 21], and germ cell tumors [35–37], as well as in leukemias [14, 38, 39]. Here, SALL4 is linked to hepatocellular carcinoma.