PARP1 and melanoma: Since TCGA database analysis revealed that melanoma samples display deregulated expression and/or mutations of the genes encoding DSB repair proteins (Figure 1), we hypothesize that DSB repair deficiencies could sensitize individual melanomas to PARP1 inhibitor administered either alone or in combination with DSB-inducing genotoxic agents, such as dacarbazine (DTIC) [11].