Moreover, regardless of the family history of breast cancer, rs2981578 shows a protective effect in women of a younger age, with lower BMI, higher education, younger age at menarche, premenopausal status, fewer menstruation years, younger age at first live birth, fewer live births, shorter period of breast feeding, ER positive, HR positive, and Luminal type or HER-2 overexpression type. This evidence concerns the gene ESR1 and breast cancer.