Meanwhile, among women of a younger age, with lower BMI, lower education, a younger age at menarche, postmenopausal status, older age at menopause, more menstruation years, older age at first live birth, longer period of breast feeding, ER positive, HR positive, and with Luminal or HER-2 overexpression type, the association for rs2290203 is significant, regardless of the family history of breast cancer. Here, ESR1 is linked to breast cancer.