ESR1 and breast carcinoma: Regardless of BMI, age at menarche, and the length of the breast feeding period, rs12922061 can increase the risk of breast cancer, and a significant association is observed in women of older age, higher education, premenopausal status, more years of menstruation, younger age at first live birth, more live births, without family history of breast cancer, ER positive, HR positive, and Luminal or HER-2 overexpression type.