NFE2L2 and acute lymphoblastic leukemia: Ingenuity Pathway Analysis (IPA) identified the Nrf2-mediated oxidative stress response to be one of the most affected pathways in adipocytes, with 47 genes differentially regulated down-stream of the pathway (Ingenuity® Systems, www.ingenuity.com, Table 2), implying that ALL cells were inducing oxidative stress in adipocytes.