TCF7 and anaplastic large cell lymphoma: We detected high levels of DNA methylation in the promoters of TCF7, GATA3, BCL11B, and LEF1 in ALK+ and ALK− tumors compared to CD3+ T cells from our dataset (Figure S3), which correlated with their decreased expression levels in tumors compared to CD3+ T cells, as identified by in silico analysis of previously published ALCL gene expression data (Figure 3B) (Eckerle et al., 2009).