In NPM-ALK-negative (ALK−) ALCL, recurrent driver mutations in JAK1 and STAT3 genes, as well as chimeras combining TFs with tyrosine kinases (ROS1 or TYK2) and overexpression of truncated ERBB4 transcripts, have been described (Crescenzo et al., 2015; Scarfò et al., 2016). Here, ALK is linked to anaplastic large cell lymphoma.