To identify enrichment of TF binding sites in the vicinity of CpG sites that are hypomethylated in ALK+ and ALK− ALCL tumors, we searched for common DNA sequence motifs in windows of 100 bp surrounding significant MVPs (28,255 hypomethylated CpG sites in ALK+ ALCL tumors and 1,291 hypomethylated CpG sites in ALK− ALCL tumors) using the MEME-ChIP tool and related applications within the Multiple EM for Motif Elicitation (MEME) web-based suite (Bailey et al., 2009; Machanick and Bailey, 2011). This evidence concerns the gene ALK and anaplastic large cell lymphoma.