Among genes in the cytoskeleton cluster, two cis-eQTLs were significant: PDLIM5 (PDZ And LIM Domain protein 5) and STK35 (serine–threonine kinase Clik1, also known as PDLIM interacting kinase 1), with the cancer risk alleles associating with significantly decreased and increased expression, respectively (Fig. 4d). Here, PDLIM5 is linked to cancer.