Additionally, while 1,25(OH)2D3-treated immature DC secrete higher levels of TGF-β as well as of IL-6 and TNF-α, as compared to conventional DC, 1,25(OH)2D3-treated DC show impaired secretion of proinflammatory cytokines following stimulation with LPS and IFN-γ as compared to conventional DC, except for IL-1β and IL-6 secretion by mature 1,25(OH)2D3-treated mo-DC from MS patients. The gene discussed is TGFB1; the disease is myeloid sarcoma.