The roles of SMAD3, such as in regulation of fibronectin, wound healing process, renal disease, and cell proliferation, were widely discussed in previous studies (Isono et al., 2002; Schiller, Javelaud & Mauviel, 2004; Ten Dijke et al., 2002; Wang, Koka & Lan, 2005). Here, FN1 is linked to kidney disorder.