In this case, tinnitus failed to remit after discontinuation but was eventually resolved with the use of mirtazapine [10], suggesting that perhaps this antidepressant or one with a similar effect on serotonin subtypes may be considered in cases of tinnitus (i.e., inhibiting 5-HT2A and 5-HT2C). This evidence concerns the gene HTR2A and Tinnitus.