TGFB1 and neoplasm: According to this survey iodine deficiency has impact more like promoter, not like direct cancerogenic agent through inducing increase of TSH, and TSH stimulation stimulates autocrine/paracrine regulated thyroid EGF (Epidermal growth factor) stimulated proliferation, lowering in the same time TGFβ1 (Transforming growth factor β1), which acts as a negative factor of thyroid cell proliferation, which results in increased angiogenesis and promoting tumor growth [25].