IL6 and anemia (phenotype): This study also showed that the prevaccination biomarkers for unfavorable OS were anemia, lower lymphocyte percentage, higher levels of haptoglobin, and higher levels of inflammatory cytokines (IL-6, IL-8, and TGFβ), and the postvaccination biomarkers were IL-6, IL-8, BAFF, lower lymphocyte percentage, and higher neutrophil percentage.