TNF and ischemia: Guizhi fuling capsules, composed of Cinnamomum cassia Blume (Gui Zhi), P. lactiflora Pall (Shao Yao), P. suffruticosa Andrews (Mu Dan Pi), P. persica Batsch (Tao Ren), and Poria cocos Wolf (Fu Ling), protect against cerebral infarction through TNF-α and IL-1β mRNA and protein downregulation and IL-10 and IL-10 receptor (IL-10R) mRNA and protein upregulation in the ischemia area after 2 h of ischemia and 24 h of reperfusion [54].