Chern et al. reported that 2-methoxystypandrone (2-MS), a major active component of Polygonum cuspidatum (Hu Zhang), attenuates the brain infarct size and improves the neurological function, at least partially, by preventing IκBα degradation and a reducing NF-κB-mediated iNOS and COX-2 expression in the peri-infarct cortex 24 h after transient MCAo. Here, NFKB1 is linked to brain infarction.