C-C motif chemokine receptor 2-knockout (Ccr2-KO) mice attributed insulin resistance in diet-induced obesity to the shift of from pro-inflammatory M1 macrophages into alternatively activated M2 macrophages and the reduction of anti-inflammatory cytokine interleukin-10 (IL-10) (Lumeng et al., 2007). This evidence concerns the gene CCR2 and obesity due to melanocortin 4 receptor deficiency.