Kilic et al. (72) described a patient with Tyk2 deficiency who displayed none of the other three cardinal features of HIES: atopic dermatitis and eczema, staphylococcal infections of the skin and lung, or high serum IgE concentrations; his highest recorded IgE concentration being 218 IU/mL at the age of 16 years. This evidence concerns the gene IGHE and atopic eczema.