It is not necessarily surprising that two ALS models show opposite electrophysiological changes in pyramidal neurons because, as noted, neither the specific cell types (hippocampal pyramidal cells vs. cortical motor neurons), nor the ALS model (UBQLN2P497H vs. G93A) investigated in this article are the same as those in the previous articles and the SOD1 G93A is a model of a lower motor neuron disease while the UBQLN2P497H is a model of ALS/FTD. The gene discussed is SOD1; the disease is frontotemporal dementia.