Thus it is reliable to propose that miR-204 may exert an anti-oncogenic activity in breast cancer cells by two pivotal mechanisms depicted in the working model: i) suppression of TGFβ pathway leading to cell proliferation, migration and angiogenesis repression, and ii) repression of ANGPT1 resulting in angiogenesis blockage (Fig. 9K). The gene discussed is TGFB1; the disease is breast carcinoma.