CD4 and neoplasm: Moreover, the percentages of tumor-infiltrating CD4 + CD25 + Foxp3 + Treg cells were also higher in the treated group than in the controls (Fig. 5C,F), with significant increases in the percentages of these Treg cells on days 16 (12.50 ± 1.07 and 8.38 ± 0.17%) and 24 (6.95 ± 1.17 and 2.17 ± 0.74%) (p < 0.01).