RASAL1 and renal fibrosis: The promoter hypermethylation of Rasal1, a Ras signaling inhibitor involved in Ras-mediated renal fibrosis, leads to its silencing and association with the perpetuation of fibroblast activation in experimental animal model renal fibrosis28, 29, suggesting that DNA methylation modification of a key gene would change the course of renal fibrosis progression.