PCSK1 and osteoporosis: Using a combination of techniques, including the examination of cell morphology, molecular biology, and histomorphometric investigations, the current study demonstrates that necroptotic osteocytes might be induced by TNF-α in vivo and vitro. We investigated that Nec-1 can prevent necroptotic osteocytes, mediated by RIP1/3, and inhibit osteoporosis progression in OVX rats.