AKT1 and cancer: By 4 months after tamoxifen induction, both distal and proximal regions showed HGPIN/cancer with a luminal phenotype and p-Akt expression (10.5%; n=658 p-Akt+ cells counted from a total of 6,275 cells versus 91.9%; n=6,455 p-Akt+ cells counted from a total of 7,024 cells) in all lobes of the prostate (Fig. 6f,i,I,o,r).