IL6 and systemic lupus erythematosus: PVS on neuroimaging are associated with inflammatory activity.32 PVS were associated with the inflammatory marker CRP in a large cohort (n=634) of community-dwelling older people (ß=0.12; P=0.048).5 In our study, the total SVD score and PVS were not associated with any blood measure of inflammation (ESR, CRP, interleukin-6) or with clinical SLE disease activity or disease burden score, but this may reflect the small sample.