ERBB2 and breast cancer: For example, Lapatinib (an EGFR/ERBB2 inhibitor for HER2-positive BC) sensitivity unsurprisingly correlated with ERBB2 expression and mutation status, but the strongest correlate was expression of the matrix metalloproteinase MMP28. Likewise, together with BRAF mutation, sensitivity to RAF or MEK1/2 inhibitors was recurrently associated with 67 features, including expression of the MAP kinase signalling regulators SPRY2 and DUSP4/6 (Hanafusa et al. 2002, Garnett et al. 2012).