EGFR and non-small cell lung carcinoma: Although known co-operating signalling pathways (such as MET amplification and EGFR mutation in non-small-cell lung cancer) (Bhang et al. 2015) may be simulated in cell line models, the use of PDTX models that mimic human cancer’s complexity and dynamics ensures that our ability to identify novel, clinically relevant, targeted strategies is maximised.