Variations in the level of leptin (the product of the gene largely responsible for obesity) across different ethnic groups and races is also well established.33 Human body composition is evidently a result of complex multifactorial interactions between lifestyle, culture, environmental and genetic differences,33 which vary from place to place and impact differently on the results of studies in different populations. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.